Collaborating with Everybody: Open Source Drug Discovery
- Term used is a bit undefined. Open Source, Free Drugs?
- First Open Source Project – Praziquantel
- Molecule has 2 mirror image forms. One does the job, other tastes awful. Pills were previously a mix
- Project to just have pill with the single form
- Created discussion
- Online Lab Notebook
- 75% of contributions were from private sector (especially Syncom)
- Ended up finding a approach that worked, different from what was originally proposed from feedback.
- Similar method found by private company that was also doing the work
- Conventional Drug discovery
- Find drug that kills something bad – Hit
- Test it and see if it is suitable – Led
- 13,500 molecules in public domain that kill maleria parasite
- 6 Laws of Open Scrience
- All data is open and all ideas are shared
- Anyone can take part at any level of the project
- Openness increasing seen as a key
- Open Source Maleria
- 4 campaigns
- Work on a molecule, park it when doesn’t seem promising
- But all data is still public
- What it actually is
- Electronic lab book (80% of scientists still use paper)
- Using Labtrove, changing to labarchives
- Everything you do goes up every day
- Todo list
- Tried stuff, ended up using issue list on github
- Not using most other github stuff
- Data on a Google Sheet
- Light Website, twitter feed
- Lab vs Code
- Have a promising molecule – works well in mice
- Would probably be a patentable state
- Not sure yet exactly how it works
- Competition – Predictive model
- Lots of solutions submitted, not good enough to use
- Hopeful a model will be created
- Tried a a known-working molecule from elsewhere, but couldn’t get it to work
- This is out in the open. Lots of discussion
- School group able to recreate Daraprim, a high-priced US drug
- Public Domain science is now accepted for publications
- Need to to make computers understand molecule digram and convert to representative format which can then be search one.
- Missing
- Automated links to databases in tickets
- Basic web page stuff, auto-porting of data, newsletter, become non-profit, stickers
- Stuff is not folded back into the Wiki
- OS Mycetoma – New Project
- Fungus with no treatment
- Working on possible molecule to treat
- Some ideas on how to get products created this way to market – eg “data exclusivity”
